ͼҰ ̿ȳ м ô Խ




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EAC, H, N, S-OҺмR316ȣ
(02-705-8233)
GC-MS < 800 amuм
(ش MS)
UHR-MS 204,000 Da (Accuracy 2ppm, Resolution 23,000)м
(ش MS)
Orbitrap-MS154,000 Da (Accuracy 3ppm, Resolution 100,000)мR314ȣ
(02-705-8234)
UHPLC-MS
(ش MS)
ESI-MS
(ش MS)
X
503,000 Daм
MALDI-TOF600 m/z ~м
500MHz NMR500MHz





(1) Elemental Analyzer : Thermo Flash 2000, Flash EA1112
   Spec. Ư¡
мϰ ϴ ÷ ó ġ ʰ Ȯ Dynamic Flash Combustion  ȭǸ(ȭ µ 1800) ȭ ÷ ȯ gas phase ȭǾ GC иǾ T.C.D( ) ȴ. ռ ȭй̳ Ÿ ⹰ Ǵ ⹰ ź, , , Ȳ, Ҹ ڵ мѴ. м ַ ȭչ ڽ ϴµ ڷᰡ ȴ.
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1. Measuring element : C, H, N, S - O analysis
2. Measuring range : 100ppm(0.01%) ~ 100 % for C,HNS-O
3. Accuracy : less than 0.1~0.3 % absolute
4. Sample size : up to 200 mg 
5. Sample analysis time : less than 10 min. for CHNS less than 5 min. for O
6. Detector : TCD ()
7. Ready to temperature : 20 min. ready to start temp. ( 1000 )
8. Sample weight : 0.001 mg to 5.1 g
9. Dual configuration 
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(2) GC-MS (ش) : Agilent 5977A MSD, 5973N
   Spec. Ư¡
µ ȭ ÷ е ÷ ȭ ģȭ ÷ b․ p ̿ и ̿ȭǾ quadrupole 鼭 и Ͼ Ͽ Ʈ  ÷ µ ̿ȴ.
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* 5977A MSD 
1. Mass range : 1.6 ~ 800 amu
2. Ion sourse : constructed of a solid insert material 
(user selectable up to 350) 
3. Mass filter : gold-plated monolitic quartz quadrupole 
(user selectable up to 200) 
4. EI scan sensitivity : 400 : 1 s/n 1 pg OFN
5. Detector : triple-axis high energy dynode(HED)-Electron Multiplier(EM) 
* 7890B GC 
1. Inlet maximum operating temp. : 400
2. Ppressure may be adjusted by increments of 0.001psi
3. RTL(Retention Time Locking)  
4. MSD interface 
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(3) UHR-MS (ش) : Bruker compact
   Spec. Ư¡
θ ǰ ִ м Quadrupoles TOF ķ ش м̴. ̴ Դ ϹĿ Ͽ ȥչ ϴ Ư (selectivity/filtering) ϰ Ȱ 浹(CID) Ǵ (fragment) ڷ Ͽ Ȯ м ִ. Electrospray, APCI, APPI, Nanospray ֽ̿ȭ ռ, õŽ, ȿ๰ ž 翬 о پ о߿ θ ̴.
Ư ко߿ Ȱ ǰ ִ proteomics(ܹü) ʼ MALDI-TOF MS Ͽ peptide Mass Fingerprinting database ˻ ƴ϶, MS/MS data Ͽ de-novo Sequencing Post Translational Modification ִ. , Ȯ ڷ molecular fomular ִ ռ÷ᳪ ÷ ִ.
ֿ䱸
1. Vaccum system : 5 stages, 28m/h rough pump
2. ESI dual ion funnel electrospray sourse : flow rate 1L/min~1mL/min
3. TOF Mass range : 20-40,000m/z
4. Quadrupole isolation : up to 3,000m/z
5. Quadrupole Mass range : up to 40,000m/z
6. Mass accuracy in MS & MS/MS
   : -with internal calibrant better than 1 ppm RMS Error
    -with external calibrant better than 2 ppm RMS Error
7. Mass Resolution : 23,000 FSR(full sensitivity resolution)
8. ESI sensitivity in MS positive mode: Reserpine 1pg S/N>100:1 RMS
9. TOF repetition rate : up to 20 kHz
* Forensics, toxicology & doping control
* Food & environmental testing
* Synthetic chemistry support
* Drug metabolite and impurity identification and quantitation
* Metabolomics
* Intact protein analysis & characterization of biopharmaceuticals
* Biomarker discovery & validation 
(4) Orbitrap UHPLC-MS (ش)
    : Ultimate 3000 Binary / LTQ Orbitrap XL (Thermo scientific)
   Spec. Ư¡
̺긮 м ׷(fg) ִ м , Ȯ(<3ppm for 1week) ش(>100,000), ڱ ܰ ϸ鼭 ִ (MSn, n=10), //Ȱ ִ ڵȭ ƾм ̴. Ӹ ƴ϶, ʹ ٸ мø ۾ ʾƵ Ǹ ⸦ ü ʾƵ Ǵ FT(ǻƮ) / Ѵ. Ư ΰ мⰡ ϳ ý յ Ư ̰ ϰ ִ м⿡ 1)MSn(n=10) Ͽ ɵ ְ м , 2) ȹ Ͽ ġ ȹ ϰ, 3) м꼺 ſ ϴ.
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1. Ultra High-performance liquid chromatography

 
A. Pump Flow Range : 0.1-10 mL/min
 
B. Pump Pressure Range : > 620bar (9000 psi)
 
C. Minimum Sample Required : < 1 L out of 5 L (250 L conical vial)
 
D. Injection Cycle Time : < 15 seconds for 5 µL
 
E. Column Compartment Temperature Range
     : 5 C to 80 C (max. 18 C below ambient)
 
F. Vacuum Degassing : 6 channel degasser
 
G. Eluent Bottle Capacity: x4 1L bottles

2. Hybrid Linear Ion Trap – Orbitrap Mass Spectrometer

 A. Mass range : 50 to 4,000 Da (Orbitrap detection)
                     
15 to 4,000 Da (Ion Trap detection)
 
B. Resolution : Maximum 100,000 at m/z 400
 
C. Mass accuracy
    : <3 ppm RMS error with external calibration
     
<1 ppm RMS error with internal calibration
* Forensics, toxicology & doping control
* Food & environmental testing
* Synthetic chemistry support
* Drug metabolite and impurity identification and quantitation
* Metabolomics
* Intact protein analysis & characterization of biopharmaceuticals
* Biomarker discovery & validation 
(5) ESI-MS (ESI, ش) : Varian 500-MS
   Spec. Ư¡
LC/MS ռȭչ ڱ Ȯϰ پ پ ÿ ϴ ̴. Liqid Chromatograph м ÷Ḧ ؼ, Mass Spectrometer м Ȯϰ мϱ System. 
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1. Analyzer
• Mass range : 50 to 3000u
• Resolution : <0.5u FWHM over the entire range
• Mass axis stability : 0.1u over 24 hours at constant (+/-3C or +/-6F)
• Scan rates : 5000 and 15000 Da/sec
• Max ion time 500,000 sec
• Enhanced Charge Capacity (ECC)
• He damping gas : 0.1 mL/min to 7.0 mL/min, typical 0.8 mL/min
• Linear dynamic range
  : up to 105, compound-dependent based upon analytical methods

2. Electrospray Ionization Source (ESI)
• LC flow range : 1 to 1000 L/min
• Needle voltage : 6 kV max
• Nebulizing gas : 1.5 L/min typical

3. Built in Syringe Pump and diverter valve
• Accommodates syringe volumes from 100 L to 10 mL
• Flow range : 0.05 mL/min to 1 mL/min (Depending on syringe size)

4. Performance Specifications
• +ESI MS/MS (full scan) : 250fg reserpine S/N 100:1, based on RMS noise

5. Detection System
• Detector : off-axis design, 15 kV HED and electron multiplier

6. Vacuum system
• Dual turbo molecular pumps, 280 L/sec each
• Ion gauge, manifold: Bayard-Alpert gauge tube with burn-out resistant,
thoria-coated iridium (ThO-Ir) filaments
• Thermal vacuum gauge, foreline
• Dual HS652 Foreline Pumps
Dual stage, rotary vane
Voltage : 100/120/230 V (universal voltage)
Pumping speed greater than 340 L/min (20 m3/hr)

7. Chromatography Options
• AutoSamplers : ProStar 410
• Solvent Delivery Modules : ProStar 212
• Detectors : ProStar 325
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(6) MALDI-TOF : Bruker Autoflex speed
   Spec. Ư¡
Ʈ Ż ̿ȭ-ð м MALDI ̿Ͽ, Ÿ̵ , ̿Ŀ ߰߰ , ٻ м DNA м ǽ ִ ̴. ü Ƽ 1kHz ̿Ͽ 2-50m ش ̹¡ ִ ġ̴. ռ м Ȱ ִ ġν, 500kDa ̻ ſ ū м ִ ɷ ϰ ִ. 
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1. lon source
   : 4 , 20 mm/min, xy stage  
2. Smartbeam- laser system 
   : 10 Ǵ ش , 1kHz , 
     - xy gate : 5 м , 100J/pulse , 1x10^9 shots  
3. Sample target
   : 384 loading positions, Barcode tracking  
4. Analyzer
   : Flash Detector technology, ̿/̿ ۵  
5. High energy CID ׼ 
* Protein, Ÿ̵ м
* м 
* Small molecule м
(7) 500MHz NMR : Varian Unity Inova 500
   Spec. Ư¡
ɾڼ I ڱӿ 2I+1 ´. ϴ Ⱑ NMR б̸, б⿡ Fourier transform Ͽ Լ NMR Ʈ ȴ. ð ٸ Ʈ ǰ ÷Ḧ м Ư ( ΰϰų ü󿡼 Ҿ Ǵ ) ϰ ҷε м ϴ. ÷ ı ȸ ϰ мð ªٴ ִ.
ֿ䱸
1. Probe 
• 5mm Indirect Detection Probe VT 
   : VT(-50~160) ϸ ⹰ ܹ Ȯο ַ . 
• 5mm Switchable Probe VT
   : 1H/19F~15N/31P(50~202 MHz) . VT(-150~160) .
     ü ´. Ϲ 13C ַ Ѵ.
• 10mm Broadband Probe VT 
  : 10mm NMR tube ϸ VT(-50~160)  
2. Mainbody : UNITY-INOVA 500NB High Resolution NMR console
                   RF 2 channel (Observe, pulse, decouple)
  : 12~60.5 MHz ,499.5~500.5 MHz
   WALTZ 16, GRAP, XY 32, MELV 16 pulse
   Variable Temperature controller
   Gradient Module
3. Mangnet : 11.8T 51-mm Bore superconducting Magnet
                 RT shims - 23 channel shims supply 
                 500MHz Z PFG upper Barrel
4. Computer : Ultra 1 Model 140 computer
                  64 Mbytes memory, 2.1G internal hard disk
                  143 MHz, 64 bit Ultra SPARC architecture (solaris 6.01a)
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